Medical Dude

Amyloidosis Spleen may have 2 patterns

• LARDACEOUS SPLEEN: associated primarily with deposition in the stroma of the Red pulp and
• SAGO SPLEEN: associated with deposition in the stroma of White pulp

Spleen may be normal sized or moderate to markedly enlarged.

The Cut surface shows one of the 2 patterns;

Lardaceous spleen : The slice of spleen is identified by its dark colour and presence of notches (1). it is characterised by diffuse map -like areas of pale ,waxy translucency.

or

Sago spleen The slice of spleen is identified by its dark colour and presence of notches (1). The sectioned surface shows presence of pale waxy translucency seen around the gray central arterioles (2) forming nodular pattern , it is seen as multiple pale foci corresponding to the regions of splenic follicles.

SPECIAL STAINS  of AMYLOIDOSIS:

• STAIN ON GROSS:Lugol’s Iodine
• H & E Staining
• Metachromatic Stains( Rosaniline Dyes)
• Congo Red & Polarised Light
• Fluorescent Stains:thioflavin-T
• Immunohistochemistry

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